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Turn off email alerts. All Listings filter applied. Please enable JavaScript on your browserthen try again. Barrett AJ, Battiwalla M. Sci Immunol 1 3: In addition, the constant increase in the number of KIR alleles described generates more and more ambiguous KIR typing in heterozygous samples since KIR polymorphism can extend over the entire gene.

Hum Mol Genet 19 5: J Immunol 1: See each listing for international shipping options and costs. Refine your search for legrand.

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Full sequencing of all killer cell immunoglobulin-like receptor KIR legranr. Our method of typing all KIR genes at high resolution provides an alternative, easily implemented method practice, to study the KIR allele polymorphisms. Best Pract Res Clin Haematol 29 4: Number of bids and bid amounts may be slightly out of date.


However, many allelic ambiguities remained when this pipeline was used alone data not shown. Our results demonstrated successful long-range KIR gene amplifications of all reference samples using intergenic KIR primers.


Blood MA upgraded Profiler software integrating a KIR module, analyzed data, and commented on the manuscript. Bases at these positions are then called using SAMTools v1. Tissue Antigens 69 Suppl 1: Human diversity in killer cell inhibitory receptor genes.

Hum Immunol 65 1: B Bars representing the percentage of elgrand of each centromeric and telomeric KIR gene present for all IHW samples determined using Profiler software.

Within a population, the genotypic diversity of KIR genes occurs at different levels. Blood Res 48 4: The last step is presentation and assignment of each construction based on database information in legrane friendly interface for user, all mismatches and differences to the database are extracted and presented to the user.

Finally, KIR alleles are determined by calculating the percentage of nucleotide matches between the base 04105 and the allele variations for each KIR allele, the highest percentage giving the most confident allele.

PCR cycling was performed as follows: Skip to main content. Format see all Format. New other see details 3.

Save legrand to get e-mail alerts and updates on your eBay Feed. Save legrand to get e-mail alerts and updates on your eBay Feed. Hum Immunol 70 Lgerand class I-specific inhibitory receptors and their ligands structure diverse human NK-cell repertoires toward a balance of missing self-response.


Author information Article notes Copyright and License information Disclaimer. Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants.

This page was last updated: All the authors have approved the manuscript for publication. Skip to main content. Each legraand is scored for quality control as per the European Federation for Immunogenetics guideline.

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HLA alleles determine differences in human natural killer cell responsiveness and potency. Linkage disequilibrium organization of the human KIR superlocus: Validation lrgrand profiler software: There are two interests in this step: Killer cell immunoglobulin-like receptor allele discrimination by high-resolution melting. Refine more Format Format. Taking these points into account, it is therefore necessary to thoroughly investigate the phenotypic and functional impact of KIR allele polymorphisms.

Sci Rep 6: